منابع مشابه
Ascorbic acid in aromatic hydroxylation. I. A model system for aromatic hydroxylation.
Studies in this laboratory on the conversion of tyramine to hydroxytyramine by homogenates of adrenal medulla showed that hydroxylation occurred maximally on the addition of ascorbic acid. Further investigation revealed that the hydroxylation did not require adrenal tissue, but could occur in the presence of ascorbic acid and oxygen. This observation led to a study of the r61e of ascorbic acid ...
متن کاملAscorbic Acid in Aromatic Hydroxylation I. a Model System for Aromatic Hydroxylation* by Sidney Udenfriend, Carroll T. Clark, Julius Axelrod, and Bernard
Studies in this laboratory on the conversion of tyramine to hydroxytyramine by homogenates of adrenal medulla showed that hydroxylation occurred maximally on the addition of ascorbic acid. Further investigation revealed that the hydroxylation did not require adrenal tissue, but could occur in the presence of ascorbic acid and oxygen. This observation led to a study of the r61e of ascorbic acid ...
متن کاملHydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents.
The C-8 position of deoxyguanosine (dGuo) was hydroxylated by ascorbic acid in the presence of oxygen (O2) in 0.1 M phosphate buffer (pH 6.8) at 37 degrees C. Addition of hydrogen peroxide (H2O2) remarkably enhanced this hydroxylation. The Udenfriend system [ascorbic acid, FeII, ethylenediaminetetraacetic acid (EDTA) and O2] was also effective for hydroxylation of dGuo in high yield. Guanine re...
متن کاملNew lipophilic piceatannol derivatives exhibiting antioxidant activity prepared by aromatic hydroxylation with 2-iodoxybenzoic acid (IBX).
Piceatannol (E-3,5,3',4'-tetrahydroxystilbene) is a phytoalexin synthesized in grapes in response to stress conditions. It exhibits strong antioxidant and antileukaemic activities due to the presence of the catechol moiety. To modify some physical properties like solubility, and miscibility in non-aqueous media some new previously unreported piceatannol derivatives having lipophilic chains on t...
متن کاملAscorbic Acid Metabolism in Rats
1. The effect ofdietary molybdenum on the growth rate and also on ascorbic acid metabolism in rats was studied. An excess of dietary molybdenum resulted in growth retardation and loss of weight. Tolerance to molybdenum was affected by the nature ofthe molybdenum salt administered. 2. Molybdenum ingestion altered certain aspects of ascorbic acid metabolism in rats. The conversion ofD-glucuronola...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1954
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)65599-1